P5.chun2010

Chun 2010 counting

전체 counting policy 메인으로 돌아가기
Label

Chun 2010 IWGMC MDS counting

Basis

Chun et al. 2010 / IWGMC MDS consensus approach

Scope

Whole sample

Clone handling

Independent clone abnormalities are added across the sample, but recurrent identical changes are counted once.

Weighting

One top-level item equals one count; tetraploidy counts as one abnormality.

When to use

Use when reproducing the IWGMC MDS counting convention.

Summary

Counts one aberration per top-level item, aggregates independent clone abnormalities across the sample, and counts the same specific abnormality only once across clones.

Algorithm

  1. Treat each top-level abnormality item as one countable aberration.
  2. Aggregate independent abnormalities across the sample.
  3. Deduplicate the same specific abnormality when it recurs across clones.
  4. Use one count for complex structural items rather than expanding by disrupted chromosome count.

Counted units

  • Each comma-separated top-level acquired abnormality generally contributes one.
  • Tetraploidy/polyploidy contributes one when it is an acquired clonal abnormality.
  • Markers count by explicit marker copy count when multiplicity is stated.

Exclusions and collapse rules

  • The same recurrent abnormality is counted once across clones.
  • Nested components inside one top-level derivative are not counted as separate top-level Chun items.
  • Constitutional polymorphism-style events are excluded when marked as constitutional.

Examples

  • del(7)(q22),+1~3mar contributes 1 for del(7) plus 3 marker copies.
  • A complex der(...) item contributes one top-level item under this convention.

Notes

  • This policy is useful for reproducing IWGMC/MDS-style abnormality totals.
  • It intentionally differs from ISCN Table 7 derivative weighting.

Source Documents

  • docs/counting_abnormalities/references/chun.pdf
  • paper/chun_table1_counting_comparison.md