P3.iscn2024
ISCN 2024 counting
Counts sample-level distinct abnormalities using ISCN 2024 section 6.5, Table 7, and the worked examples in Table 8.
- Scope
- Whole sample
- Basis
- ISCN 2024 section 6.5 and Table 7
Abnormality Counting
Counting policy documents
Overview
CytoMut exposes several counting policies because ISCN-oriented review, MDS, AML, and CLL workflows use different counting conventions.
P9.event_collapsed
Event-collapsed counting
Starts from ISCN Table 7 sample-level weighting, then absorbs compensatory whole-chromosome gains into accompanying unsigned replacement derivatives.
- Scope
- Whole sample
- Basis
- CytoMut custom policy built on Table 7 weights plus biological-equivalence collapse rules
P5.chun2010
Chun 2010 counting
Counts one aberration per top-level item, aggregates independent clone abnormalities across the sample, and counts the same specific abnormality only once across clones.
- Scope
- Whole sample
- Basis
- Chun et al. 2010 / IWGMC MDS consensus approach
P8.grimwade2010
Grimwade 2010 counting
Counts independent abnormalities across the sample using Grimwade-style related-event, multiplicity, derived-gain, and unbalanced-translocation rules.
- Scope
- Whole sample
- Basis
- Grimwade et al. 2010 AML complex-karyotype framing
P6.haase2019
Haase 2019 counting
Applies Chun-style top-level counting in the single clone lineage with the highest total, with unbalanced translocations counted as two abnormalities.
- Scope
- Highest-abnormality clone lineage
- Basis
- Haase et al. 2019 / IPSS-R single-clone complexity framing