P8.grimwade2010

Grimwade 2010 counting

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Label

Grimwade 2010 AML counting

Basis

Grimwade et al. 2010 AML complex-karyotype framing

Scope

Highest-abnormality clone lineage

Clone handling

Uses the single clone lineage with the highest total abnormality count.

Weighting

Unbalanced derivative/translocation events can contribute more than one count.

When to use

Use for AML complex-karyotype interpretation in a Grimwade-style framework.

Summary

Counts top-level abnormalities in the highest-abnormality clone lineage, with unbalanced derivatives/translocations expanded by disrupted chromosome count.

Source Documents

docs/counting_abnormalities/references/2010_grimwade_blood.pdf
paper/abnormality_counting_methods_and_policies.md